TRT Methods – The Treatments Available

TRT Methods – The Treatments Available

There are many different ways to administer TRT - do your research before committing.

tl; dr ... Short and to the Point
Who is this article aimed at?
Anybody trying to evaluate TRT and decide what the pros and cons are of the different methods. Anyone looking for a quick overview of TRT options without being baffled by technical medical terminology.
I am busy - summarize it for me

Not only are there a bewildering array of options when it comes to TRT, there are more coming through the pipeline all the time. Ultimately your choice depends on a number of factors - age, medical history, budget, lifestyle, where you live, etc .

There is no one best answer, you will have to weigh up the options depending on your own circumstances.

QuickShot – More convenient TRT?

A new Testosterone Replacement Therapy going by the tradename of ‘QuickShot Testosterone’ has completed it’s Clinical Trial Phase 3. The product is administered subcutaneously once a week to males suffering from hypogonadism.

The company behind the product us New Jersey, US based Antares Pharma. It specialises in products which can be injected using innovative methods – self administered injection pens, auto injectors, multi-use pen injectors and reusable needle-free injectors.

So…it doesn’t take a genius to work out that it’s a product designed to be easily auto-administered.

QuickShot is primed (should the FDA be persuaded of it’s clinical merits) to occupy a gap in the market for an effective product that can be easily and safely auto-administered.

(Update – 27th Febuary 2017: Since first publishing this article in November 2015, QuickShot Testosterone’s manufacturers, Antares Pharma, Inc have announced that the New Drug Application (NDA) for their product has been accepted.

The hormone delivery system will now take the next step towards being available for to the public, a standard review by the FDA.

The date set for the Prescription Drug User Fee Act (PDUFA) is October 2017, 10 months on from the NDA first being submitted. This date is the target for the FDA to complete their review of the Quick Shot Testosterone’s application)

In this article we take a look at the different methods TRT is applied, and their pros and cons.

Traditional TRT Methods

Before we finish this article, it’s well worth having a look at some of the other TRT product, how they are applied and used.


Intramuscular Injections

Free testosterone has a half life of ten minutes. For those of you not paying attention in Chemistry, this means that every ten minutes the levels of effective free test halve. So after thirty minutes levels are 1/8 of the original. After 1 hour they are 1/64.

That is perishable. The test is therefore esterified in oil to make it last longer, and can be injected into muscle (ie your backside or arm) by virtually anybody using a basic needle that cost next to nothing. Job done.

Pros: Quick, cheap and easy

Cons: The injections are deep and may cause pain. Inconvenient having to attend clinics to receive injections from a physician or nurse. The testosterone is not released in a nice steady manner. Users are likely to get a surge in 2 to 3 days and then a horrible dip after 1 to 2 weeks.

These yo-yo hormone levels are not conducive to a harmonious home life, and will cause swings in mood, energy and libido. When the dosages are higher, the trips to the clinic are less frequent but the hormone swings are more pronounced.


Implants

This is nothing new, testosterone implants have been around since the 40s. Th testosterone is in crystal form in pellets which are inserted under the skin and release slowly over a period of around 6 months.

Pros: Delivers a steady release, you don’t get the wild swings associated with intramuscular injections.

Cons: Requires a surgical procedure, which will always be expensive and carry it’s own risks. 3 to 6 pellets inserted under the skin around the thighs and abdomen can be painful and the body will often reject them. Not simple to remove once implanted should side effects occur.


Transbuccal Testosterone

A modern deployment technique, the test is in the form of small tablets which you insert twice a day into your mouth and it’s absorbed through the gums.

Cleverly, the testosterone is more effective when absorbed in this manner as it gets into the bloodstream quicker meaning less of it is metabolised by muscular tissue.

Pros: Easy and convenient to take. Effective.

Cons: Doesn’t taste very nice, can cause irritation. Also the testosterone can be transmitted via saliva so if your wife starts developing a hairy chest you need to reduce the sloppy kissing.


Transdermal Testosterone

A patch or gel applied once a day. Patches were initially developed for direct application to the scrotum. As you can probably imagine, this went down like a shit sandwich amongst users – who had to shave their scrotum and then have a big sticky patch on it. Alternative non-scrotal methods were quickly developed.

Pros: Mimics testosterones own rhythm, with a spike in the morning and a decline into the night. Easy to stop – you just stop applying the patches.

The gel it is more effective at allowing the body to absorb testosterone, as it can cover greater surface area – however it’s more prone to accidental transferrence to other people (ie wife, kids etc) so users have to cover up. They also have to prevent swimming or showering for up some hours after applying it.

Cons: Wide variation in absorption rates between individuals, no guarantee how effective it’ll be for any one person. Patches have the same drawbacks as nicotine replacement patches in that they routinely cause skin irritation. The gel is VERY expensive.


Oral Testosterone

This is a far less common way of ingesting TRT, and is mainly confined to Europe as the testosterone derivative used was never approved in the USA. Not new, been around a long time.

Pros: Easy to take, no pain. Can be stopped easily if side effects occur.

Cons: Rare reports of hepatotoxiticy and risks for some other hepatic complications but otherwise it’s considered safe. Testosterone levels vary and you’ve got to remember to take it a number of times a day.

Conclusion

There are a whole range of methods by which TRT is administered, each with it’s own drawbacks.

Each one should be evaluated on it’s own merits. It may be that certain options are not available to you because of where you live, your medical record or your budget.

It’s worth researching the options available, and it’s reassuring to know that new innovative delivery methods are being created all the time.

tl; dr ... Short and to the Point
Who is this article aimed at?
Anybody trying to evaluate TRT and decide what the pros and cons are of the different methods. Anyone looking for a quick overview of TRT options without being baffled by technical medical terminology.
I am busy - summarize it for me

Not only are there a bewildering array of options when it comes to TRT, there are more coming through the pipeline all the time. Ultimately your choice depends on a number of factors - age, medical history, budget, lifestyle, where you live, etc .

There is no one best answer, you will have to weigh up the options depending on your own circumstances.

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